:Abstract
Oxidative stress plays an important pathogenetic role in many chronic inflammatory
diseases, including those of dermatological interest. In particular, regarding psoriasis, vitiligo, and
lichen planus, excess reactive oxygen species and a decline in endogenous antioxidant systems are
observed. In this regard, treatments with antioxidant properties could be appropriate therapeutic
options. To date, clinical trials in dermatology on these treatments are limited. We reviewed the
available studies on the efficacy of antioxidant therapies in psoriasis, vitiligo, and lichen planus. The
role of herbal derivatives, vitamins, and trace elements was analyzed. The antioxidant properties of
conventional therapies were also evaluated. Data from the literature suggest that antioxidants might
be useful, but available studies on this topic are limited, heterogeneous, not completely standardized,
and on small populations. Furthermore, in most cases, antioxidants alone are unable to induce
significant clinical changes, except perhaps in mild forms, and must be used in conjunction with
standard drug treatments to achieve measurable results. Further studies need to be conducted,
considering larger populations and using internationally validated scales, in order to compare the
.results and clinical efficacy
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